Perdoem-nos pela falta de postagem por um longo tempo, muitas provas, sabem como é que é né? Mas vamos reparar isso. Ok, enfim...Vinha pesquisando para nosso blog algo relevante e me deparei com o Sistema Renina-Angiotensina-Aldosterona (SRAA), totalmente importante para a regulação da pressão dos vasos.(Aliás, galera da nutrição, aula de histologia se tratou disso!)
Esse sistema consiste, primeiramente, na liberação de renina, um composto formado quase que exclusivamente nos rins, mais precisamente no aparelho justaglomerular (células musculares lisas modificadas) e cai na corrente sanguínea até chegar ao fígado. Lá, um outro composto, o angiotensinogênio, age sobre a renina transformando-se em angiotensina I. Esta vai se dirigir aos pulmões e sob ação da ECA (Enzima Conversora de Angiotensina) sofrerá hidrólise e se transformará na substância final, angiotensina II. Depois desse longo caminho, esse produto final vai ser o ponto chave para a realização da função do sistema. A angiotensina II vai ser responsável pela vasoconstrição e pela liberação de aldosterona que por sua vez é responsável pela retenção de sódio e água, mantendo o equilíbrio hemodinâmico do corpo. Segue um esquema pra vocês não se perderem:
Ta...E o que a hipertensão tem a ver com isso? Pelo o que se pode perceber, esse sistema está relacionado à elevação da pressão, e quando há uma hiperatividade do mesmo a nossa doença em questão entra em cena. A ativação excessiva do SRAA pode ocasionar também progressão de lesões de órgãos-alvo como hipertrofia ventricular esquerda, insuficiência cardíaca congestiva, hipertrofia vascular, alterações renais e etc. Ainda há outro motivo relacionado ao SRAA que aumenta a pressão sanguínea de acordo com Sealey e Laragh: A renina (aquela primeira substância secretada pelos rins) é estimulada quando há baixa volemia e baixa pressão sanguínea, fazendo com que a normalidade volte. Porém, com uma dieta hipersódica e conseqüentemente o aumento da pressão(retenção de água para os vasos), esse estímulo de produção de renina não diminui agravando mais ainda a hipertensão (já estabelecida, nesse caso).
Ainda bem que existe solução para tais problemas, ou tentativa do mesmo: Os anti-hipertensivos, mas isso é assunto para um próximo post.
Bons Estudos!
Mariana Cyncynates
Fontes:
http://departamentos.cardiol.br/dha/revista/7-3/016.pdf
http://www.medonline.com.br/med_ed/med3/rimehipert.htm
http://resultados.hormocentro.com.br/Lab/Instrucoes/I0105.html
66 comentários:
ajudouu muito...vlw pela explicação!!!!!!!!estudo biomedicina.....e esse Sistema dava me dando pesadelos...rsrs
Adorei sua explicação, me ajudou mega a relembrar as aulas de fisiologia...
Sou estudando de nutrição do Rj e amei o blog! Parabéns!
Me ajudou bastaante.
Sou estudante de Enfermagem ,e fico muito grato pela a explicação do sraa!
valeu a explicação,agora o sraa ficou bem mAIS CLARO PARA MIM E PARA SUPER PROVA DE FISIOPATOLOGIA.
adorei a explicaçao entendi tudo muito melhor que o FDP do meu professor de fisiologia que conseguiu tornar um sistema simples em uma coisa complexa e dificil de entender. VALEU PWLA AJUDA. Ah e adorei o esqueminha ficou otimo!!! :)
Faço enfermagem, muito simples sua explicação é sempre bom relembrar esse sistema tão importante.
Obrigada, muito didatico seus resumos,,,,,
Um adenoma na supra renal pode interferir na formação da angiotensina II? Ele pode ser responsável por um quadro de hipertensão?
excelente explicação! mt, mt claro agora!! faço enfermagem na UESC ( Ilhéus-Bahia)
Adorei a explicação!! Faço Educação Física na Universidade Federal mdo Espírito Santo (ES) e esta disciplina esta me deixando doida.... Parabéns
21/01/2012
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